Chaga Mushroom Extract | Inonotus Obliquus

Chaga Mushroom Extract | Inonotus Obliquus

Chaga mushroom (Inonotus obliquus) has long been used as a folk medicine due to its various biological functions, such as antibacterial, antiallergic, anti-inflammatory, and antioxidative activities. In the present study, researchers found that the I. obliquus hot water extract (IOWE) activated the adipogenesis of 3T3-L1 preadipocytes. Even without the adipogenic stimuli provided by insulin, the IOWE strongly induced the adipogenesis of these preadipocytes. The major component of IOWE was glucose-rich polysaccharides with a molecular mass of 149 kDa. Chaga Mushroom Extract | Inonotus Obliquus

IOWE enhanced the differentiation of 3T3-L1 preadipocytes, leading to an increase in TG (triacylglycerol) accumulation, which is critical for the acquisition of the adipocyte phenotype, in a dose-dependent manner. IOWE stimulated the gene expression of C/EBPα (CCAAT/enhancer-binding protein α) and PPARγ (peroxisome proliferator-activated receptors γ) during adipocyte differentiation and induced the expression of PPARγ target genes, including aP2 (adipocyte protein 2), LPL (lipoprotein lipase), and CD36 (fatty acid translocase). Immunoblot analysis revealed that IOWE increased the expression of adipogenic markers such as PPARγ and GLUT4 (glucose transporter 4). The luciferase reporter assay demonstrated that IOWE did not exhibit PPARγ ligand activity.

Although these findings require further investigation, the ability of natural mushroom products to enhance PPARγ transcriptional activities may offer therapeutic targets for dyslipidemia and type 2 diabetes.

Why You Should Trust Truffle Mushroom Center

I’ve recommended Truffle Mushroom Center to several friends who were also looking to buy magic truffles online, and they’ve all had excellent experiences. Between their high-quality products, fast shipping, and reliable customer service, this vendor has truly earned my trust.

Whether you’re a beginner looking to dip your toes into the world of psychedelics or an experienced user searching for your next trip, I can’t recommend Truffle Mushroom Center enough.